There is a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to lessen afferent discomfort transmission and make analgesia. For that reason, prescription drugs like clonidine that target alpha-2 receptors can influence the transmission of ache. Applies to clonidine: https://www.proleviate.com/post/the-new-pain-killer-conolidine