This methylation profile is already acquired for the MBL stage3 and remains rather stable as time passes. Even so, some CLL have intratumor variability in sure locations, which may change the expression of numerous genes and facilitate tumor evolution.71 Of note, this variability is larger in U-CLL than in M-CLL https://mbl7734444.ka-blogs.com/85650081/situs-judi-mbl77-no-further-a-mystery