Daily life-threatening respiratory melancholy and death have transpired in small children who been given codeine. Most of the claimed instances occurred pursuing tonsillectomy and/or adenoidectomy and several of the kids had evidence of staying ultra-rapid metabolizers of codeine due to a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, Safety measures; https://wockusa.com/product/actavis-legal-lean/