This mechanism is most likely in the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical reaction to doxycycline should be monitored intently. Phenytoin, sodium valproate, valproic acid: The result of barbiturates over the metabolism of phenytoin seems for being variable. https://franceso135the4.theideasblog.com/profile